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The study opens the door to new treatment strategies for breast cancer

The study opens the door to new treatment strategies for breast cancer



Theodoros Fukakis. Photo: Ioana Markacki

We used several “omic” analyzes to investigate metabolic reprogramming within the tumor microenvironment in breast cancer and study whether and how it develops during NAC. “We have identified vulnerabilities in immune metabolism with potential to be exploited in combination immunotherapy strategies,” says Theodoros Fukakis, a researcher at the Department of Oncology and Pathology at Karolinska Institutet, who led the study.

Importance for future treatments

The researchers discovered that changes in immune status, tumor metabolic proteins, and tumor cell gene expression correlate with response to treatment. The results demonstrate the potential to target tumor metabolism to improve the effectiveness of immunotherapies. By understanding the dynamic relationship between the intrinsic metabolic state of the tumor and the tumor microenvironment, new prognostic biomarkers and therapeutic targets may emerge, paving the way for precision medicine in breast cancer treatment.

This study not only highlights the complex ecosystem of breast cancer, but also opens the door to new treatment strategies that can significantly improve patient outcomes. The study's characterization of the genomic and proteomic landscape of breast cancer represents a promising direction for future cancer research and therapeutics.


Longitudinal molecular profiling elucidates immunometabolic dynamics in breast cancer.
Wang K, Zerdis I, Johansson HJ, Serhan D, Sun Y, Kanellis DC, Sivakis EJ, Miziewski A, Liu Fukakis T
Nat Commun 2024 May;15(1):3837

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