New thesis: The role of inflammatory cells in sarcoidosis and asthma

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Mo Ne, what is the topic of the thesis and can you tell us about any findings?

In the first part of my thesis, I explored the role of mononuclear phagocytes in the pathogenesis of pulmonary sarcoidosis. We found that pulmonary monocytes contribute to inflammation in sarcoidosis by producing TNF, which is also associated with disease progression. Furthermore, circulating lung dendritic cells from sarcoidosis patients stimulate T cell proliferation with a Th1 phenotype.

The second part aims to study the role of inflammatory cells that infiltrate the airways in allergic asthma. Initially, monensin was identified as an effective substance for reducing mast cell numbers and thus attenuating airway constriction induced by mast cell-associated antigen in both isolated guinea pig and human airways. Further experiments with monensin In vivo Highlights the critical role of mast cell hyperplasia in the development of airway hyperactivity and inflammation in allergic asthma. By overcoming post-mortem bronchoconstriction in guinea pig lungs, the definitive study demonstrated that guinea pig intralobular bronchioles have many pharmacological similarities to human bronchioles. By combining the newly established guinea pig intralobular trachea model with the modified model In vivo model of allergic asthma in guinea pigs, allergic airway inflammation has been shown to enhance the mast cell response, highlighting the importance of mast cells in the pathophysiology of allergic asthma.

Thesis link: The role of inflammatory cells in sarcoidosis and asthma

About the thesis

time: April 23 at 9.00 am
location: Biomedicine, Room A0315 (Peter Richard)

Main supervisor
Associate Professor Michael Adner
Asthma and Allergy Experimental Research Unit
Institute of Environmental Medicine, Karolinska Institutet

Co-moderators
Professor Gunnar Nelson
Department of Immunology and Allergy
Department of Medicine, Solna, Karolinska Institutet

Assistant Professor Jesper Sevholm
Asthma and Allergy Experimental Research Unit
Institute of Environmental Medicine, Karolinska Institutet

Discount
Associate Professor Hamid Akbarshahi
Department of Translational Respiratory Medicine
Department of Clinical Sciences
Lund University