Individuals with type 2 diabetes often receive diet and exercise counseling as part of their treatment, and both interventions can affect clock and mitochondrial genes, says Brendan Gabriel, a researcher in the Department of Physiology and Pharmacology, Karolinska Institutet.
Brendan Gabriel is lead author of the study with Ali Altintas, a senior lecturer at Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) at the University of Copenhagen.
We know that sleep disturbances are associated with an increased risk of type 2 diabetes, and through our study we are now showing how these disturbances may be linked to the molecular biology of cells, says Ali Altintas.
Scientific material:
Disrupted circadian oscillations in type 2 diabetes are associated with altered rhythmic mitochondrial metabolism in skeletal muscle, (Brendan M. Gabriel, Ali Altintas, Jonathon AB Smith, Laura Sardon-Puygues, Zipeng Zhang, Astrid L. Bass, Rihanna C. Lacker, Hui Zhao, Zhengyi Liu, Lucille Dollett, Jonas Triback, Antonio Zorzano, Zhiguang Huo, Mikael Redin, Joanna T. Laner, Karen A. Esser, Romain Barré, Nicolas J. Billon, Anna Kroc, Julien R. Zerath), Advances in Science, online Oct 20, 2021
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