Antidepressant medications and risk of manic episodes in children and adolescents

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Because we did not see an association between antidepressant treatment and risk of mania/hypomania, it suggests that other factors are more important in assessing who may be at greater risk of transitioning from unipolar depression to mania. Our model using information from a number of national registries has fairly good prognostic power, demonstrating that it is possible to identify patients at high risk of developing mania/hypomania using a clinical prognostic prediction model. “We see potential to improve the model,” he says. Cheng Changsenior researcher in the Department of Medical Epidemiology and Biostatistics.

The study was conducted in collaboration with the Department of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, and funded by the Swedish Research Council (2018-02213) and the Health, Working Life and Welfare Research Council (2022-00824). .

Publishing

Virtanen S, Lagerberg T, Takami-Lageborn C, et al. Antidepressant use and risk of manic episodes in children and adolescents with unipolar depression. JAMA Psychiatry. Published online September 27, 2023. doi:10.1001/jamapsychiatry.2023.3555

* Mania: Extremely elevated mood with increased activity, restlessness/talkativeness/irritability and a markedly decreased need for sleep, which clearly derails the person, is noticeable to the environment and leads to functional impairment. It usually requires hospital care to avoid serious consequences. Disturbed perception of reality with psychotic symptoms may occur.

source: https://www.vgregion.se/ov/bipolar/vad-ar-bipolar-sjukdom/symptom/